A Single Axiom. All of Physiology.

The BRUT Framework 

Deriving cardiovascular dynamics, neural coherence, and metabolic coupling from a single partition capacity axiom: C(n) = 2n²

Core Equations

From one axiom, a complete mathematical physiology emerges.

Partition Capacity

C(n) = 2n²

The foundational axiom. The number of distinguishable categorical states at partition depth n follows a quadratic scaling law derived from spherical symmetry constraints.

S-Entropy

S = kₕ ln C(n)

Entropy over the partition hierarchy. Connects information-theoretic capacity to thermodynamic entropy via the three coordinates (S_k, S_t, S_e).

Kuramoto Coherence

Rₓ = exp(-2π²·CV²)

Cardiac coherence estimated from heart rate variability. CV = RMSSD·HR/60000 maps beat-to-beat variation to the Kuramoto order parameter.

Frank-Starling Law

SV = SVₘₐₓ · (1 - e⁻ᵏ⋅ᵢᵥ)

Stroke volume as a function of preload, derived from partition boundary conditions on the pressure-volume loop.

Cardiac-Neural Coupling

Rₙ/Rₓ = 0.87/√Rₓ

The ratio of neural to cardiac coherence follows a universal scaling law, valid during coupled states. Breaks down during REM sleep.

Consciousness Window

Δt₂ = T / (2π√(Rₓ·Rₙ))

The temporal integration window for conscious experience, derived from the geometric mean of cardiac and neural coherence.

1
Foundational Axiom
5
Derived Subsystems
17+
Testable Predictions
4
Published Papers

Derivation Hierarchy

Each physiological system is derived from the same partition axiom, forming a unified hierarchy from cardiac mechanics to conscious experience.

01

Cardiovascular Mechanics

  • Pressure-volume loops from partition boundary conditions
  • Frank-Starling, Windkessel, and baroreflex as emergent properties
  • Cardiac equations of state: PdV + VdP = C(n)kT formalism
  • Disease classification via Kuramoto regime boundaries
02

Neural Coherence

  • EEG band structure from partition depth selection
  • Consciousness as temporal integration over coherence window
  • Sleep architecture as regime traversal sequence
  • REM active decoupling: cardiac-neural gap = 0.375
03

Metabolic Coupling

  • Oxygen transport as partition-level coupling constant
  • Temperature-dependent coherence via Arrhenius formalism
  • Metabolic cost of cognitive geometries (thought metabolism)
  • Altitude degradation curves from O2-partition coupling
04

Sensor Disambiguation

  • Partition-Coupled Heart Rate (PCHR) decomposition
  • S-entropy health coordinates from wearable sensors
  • Cross-Scale Coherence Index for inter-system coupling
  • Temperature-corrected coherence removing metabolic bias

Join the Research

We are seeking collaborators with expertise in clinical cardiology, computational neuroscience, and wearable sensor engineering. Investment opportunities available for sensor disambiguation IP.